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Cruciani RA, Zhang JJ, Manola J, Cella D, Ansari B, Fisch MJ

Hepatic lipid metabolism is primarily governed by the activation of the sterol regulatory element-binding protein 1c (SREBP1c) pathway, also known as the I-Rec pathway

1 Introduction Migraine manifests as a chronic neurovascular disease characterized by unilateral or bilateral throbbing severe headaches, predominantly unilateral, recurring with symptoms such as nausea, vomiting, photophobia, and phonophobia that impair autonomic nervous system functions (Steiner and Stovner, 2023) many sufferers cannot perform normal or work activities